Used machines for sale
 Tablet disintegration test
Main brands:
2Mag, AutoPlus Multifill, Barnant Company, Citizen, Microette Plus, PolyScience
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| Tablet disintegration test |
Tablet and capsule disintegrators are equipment used in the pharmaceutical industry to evaluate the ability of a tablet or capsule to disintegrate or break down into smaller particles when exposed to a liquid medium. This test is crucial to ensure that medications are absorbed effectively by the body, as proper dissolution is essential for the absorption of active substances.
How it works:
Disintegration testing is an integral part of drug quality assessment. The process generally follows these steps:
Sample Preparation: One or more tablets or capsules are placed individually in each disintegrator container.
Liquid Immersion: The tablets or capsules are submerged in a liquid medium, usually water or a fluid simulating gastric fluid, which simulates the conditions found in the digestive system.
Disintegration: The equipment simulates the conditions of the gastrointestinal tract, applying agitation and controlled temperature. During this process, the tablets or capsules should disintegrate into smaller particles.
Note: The time required for disintegration to occur is monitored. The test may have specific acceptance criteria indicating the maximum period allowed for disintegration.
Types of Disintegrators:
Manual Tablet Disintegrators: In these devices, operators manually control the process of soaking and shaking the tablets.
Automatic Tablet Disintegrators: Automated equipment that performs the disintegration test on a programmed basis, providing greater precision and efficiency.
Capsule Disintegrators: Designed specifically to test capsule disintegration, these equipment are adapted to the shape and consistency of capsules.
High-Speed Disintegrators: More advanced equipment that can perform tests on multiple samples simultaneously, increasing efficiency.
Specific Disintegrators for Controlled Drugs: Some disintegrators can be adapted to meet specific prescription drug requirements, ensuring compliance with strict regulations.
Effective disintegration is critical to ensuring adequate availability and absorption of active ingredients in medicines. Compliance with regulatory standards is crucial in the pharmaceutical industry, and disintegrators play an essential role in quality control during drug development and manufacturing. |
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